Does glucose-6-phosphate dehydrogenase deficiency worsen the clinical features of sickle cell disease? A multi-hospital-based cross-sectional study.

Paul Kambale-KombiRoland Marini Djang'eing'aJean-Pierre Alworong'a OparaJean-Marc MinonCamille Atoba BokeleVincent BoursMarie-Agnès AzeradSerge Tonen-WolyecCharles Kayembe TshilumbaSalomon Batina-Agasa

Published in: Hematology (Amsterdam, Netherlands) (2022)

The prevalence of G-6-PD deficiency in SCD patients was high but did not differ from that observed in controls. In addition, G-6-PD deficiency appeared to worsen the clinical features of SCD. Nevertheless, prospective studies further clarifying this observation are needed.

Keyphrases

sickle cell disease
end stage renal disease
ejection fraction
newly diagnosed
chronic kidney disease
replacement therapy
risk factors
prognostic factors
peritoneal dialysis
metabolic syndrome
patient reported outcomes
skeletal muscle
glycemic control