Sinomenine Hydrochloride Protects IgA Nephropathy Through Regulating Cell Growth and Apoptosis of T and B Lymphocytes.

Jun-Jian LiLi LiShuang LiXin-Yi TangHui-Feng SunJian-Xin Liu

Published in: Drug design, development and therapy (2024)

SH exerts a dual regulation on the cell cycle and apoptosis of T and B cells by controlling cell cycle-related and apoptosis-associated proteins; it also reduces inflammatory cellular infiltration and mesangial proliferation. These are the major mechanisms of SH in IgAN.

Keyphrases

cell cycle
oxidative stress
cell proliferation
endoplasmic reticulum stress
cell cycle arrest
cell death
pi k akt
peripheral blood
diabetic nephropathy
endothelial cells
high glucose