Novel transketolase inhibitor oroxylin A suppresses the non-oxidative pentose phosphate pathway and hepatocellular carcinoma tumour growth in mice and patient-derived organoids.

Dan JiaChunliang LiuZhenyu ZhuYan CaoWen WenZhanying HongYue LiuErdong LiuLong ChenChun ChenYanqiu GuBinghua JiaoYifeng ChaiHong-Yang WangJing FuXiaofei Chen

Published in: Clinical and translational medicine (2022)

These results uncover a unique role for oroxylin A in TKT inhibition, which directly targets TKT and suppresses the non-oxidative PPP. Our findings will facilitate the development of small-molecule inhibitors of TKT and novel therapeutics for HCC.

Keyphrases

small molecule
signaling pathway
protein protein
high fat diet induced
skeletal muscle
wild type