Germline mutations in penetrant cancer predisposition genes are rare in men with prostate cancer selecting active surveillance.
Lauren BradyLisa F NewcombKehao ZhuYingye ZhengHilary BoyerNavonil De SarkarJesse K McKenneyJames D BrooksPeter R CarrollAtreya DashWilliam J EllisChristopher P FilsonMartin E GleaveMichael A LissFrances MartinTodd M MorganIan M ThompsonAndrew A WagnerColin C PritchardDaniel W LinPeter S NelsonPublished in: Cancer medicine (2022)
The frequency of pathogenic germline mutations in penetrant cancer predisposition genes is extremely low in men with PC undergoing active surveillance and pathogenic germline mutations had no apparent association with grade reclassification or adverse characteristics.