Clinicopathological and molecular correlations in traditional serrated adenoma.

Shigeki SekineSatoshi YamashitaMasayoshi YamadaTaiki HashimotoReiko OgawaHiroshi YoshidaHirokazu TaniguchiMotohiro KojimaToshikazu UshijimaYutaka Saito

Published in: Journal of gastroenterology (2020)

Our observations indicate that TSAs mostly harbor various combinations of concurrent WNT and MAPK gene alterations. The associations between genetic and morphological features suggest that the histological diversity of TSA reflects the underlying molecular heterogeneity.

Keyphrases

genome wide
copy number
signaling pathway
stem cells
cell proliferation
oxidative stress
single cell
single molecule
pi k akt
gene expression
locally advanced
radiation therapy
genome wide analysis