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Oxaliplatin induces muscle loss and muscle-specific molecular changes in Mice.

Claire E FeatherJustin G LeesPreet G S MakkerDavid GoldsteinJohn B KwokGila Moalem-TaylorPatsie Polly
Published in: Muscle & nerve (2017)
The findings suggest that oxaliplatin treatment can directly disrupt skeletal muscle homeostasis and promote muscle loss, which may be clinically relevant in the context of targeting fatigue and weakness in cancer patients. Muscle Nerve 57: 650-658, 2018.
Keyphrases
  • skeletal muscle
  • insulin resistance
  • type diabetes
  • high fat diet induced
  • single molecule
  • combination therapy
  • peripheral nerve