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GENOME REPORT: Chromosome-scale genome assembly of the African spiny mouse ( Acomys cahirinus ).

Elizabeth Dong NguyenVahid Nikoonejad FardBernard Y KimSarah CollinsMiranda GaleyBranden R NelsonPaul WakenightSimone M GableAaron McKennaTheo K BammlerJim MacDonaldDaryl M OkamuraJay ShendureDavid R BeierJan Marino RamirezMark W MajeskyKathleen J MillenMarc TollisDanny E Miller
Published in: bioRxiv : the preprint server for biology (2023)
There is increasing interest in the African spiny mouse ( Acomys cahirinus ) as a model organism because of its ability for regeneration of tissue after injury in skin, muscle, and internal organs such as the kidneys. A high-quality reference genome is needed to better understand these regenerative properties at the molecular level. Here, we present an improved reference genome for A. cahirinus generated from long Nanopore sequencing reads. We confirm the quality of our annotations using RNA sequencing data from four different tissues. Our genome is of higher contiguity and quality than previously reported genomes from this species and will facilitate ongoing efforts to better understand the regenerative properties of this organism.
Keyphrases
  • stem cells
  • genome wide
  • mesenchymal stem cells
  • single cell
  • quality improvement
  • cell therapy
  • gene expression
  • electronic health record
  • machine learning
  • dna methylation
  • big data
  • artificial intelligence
  • copy number