The protective effects of escitalopram on synaptic plasticity in the CA1 region of chronically stressed and non-stressed male rats.
Zahra FarahbakhshMaryam RadahmadiPublished in: International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience (2022)
Stress significantly attenuated neural excitability and long-term plasticity in the CA1 area. Only escitalopram 10 mg/kg improved synaptic excitability, as well as LTP induction and maintenance in non-stressed subjects even more than normal levels. However, under stress conditions, both escitalopram doses enhanced neural excitability and memory probably due to reduced serum corticosterone levels.