Sperm DNA methylation epimutation biomarker for paternal offspring autism susceptibility.

Nicolás GarridoFabio CruzRocio Rivera EgeaCarlos SimonIngrid Sadler-RigglemanDaniel BeckEric NilssonMillissia Ben MaamarMichael K Skinner

Published in: Clinical epigenetics (2021)

Observations demonstrate a highly significant set of 805 DMRs in sperm that can potentially act as a biomarker for paternal offspring autism susceptibility. Ancestral or early-life paternal exposures that alter germline epigenetics are anticipated to be a molecular component of ASD etiology.

Keyphrases

early life
autism spectrum disorder
intellectual disability
dna methylation
high fat diet
attention deficit hyperactivity disorder
gene expression
air pollution
dna repair
metabolic syndrome
type diabetes
oxidative stress
skeletal muscle