Detection of AAG repeats through DNA triplex-induced G-cluster formation.
Ha Jung LeeByeang Hyean KimPublished in: Chemical communications (Cambridge, England) (2019)
This communication describes a novel method, using DNA triplex-based fluorescent probes, for the detection of AAG repeats. A triplex structure with target DNA AAG repeats stabilizes a PyA-modified G-cluster adjacent to the triplex-forming sequence, resulting in a dramatic change in the color of fluorescence from blue to orange.