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Detection of AAG repeats through DNA triplex-induced G-cluster formation.

Ha Jung LeeByeang Hyean Kim
Published in: Chemical communications (Cambridge, England) (2019)
This communication describes a novel method, using DNA triplex-based fluorescent probes, for the detection of AAG repeats. A triplex structure with target DNA AAG repeats stabilizes a PyA-modified G-cluster adjacent to the triplex-forming sequence, resulting in a dramatic change in the color of fluorescence from blue to orange.
Keyphrases
  • single molecule
  • circulating tumor
  • cell free
  • living cells
  • label free
  • nucleic acid
  • loop mediated isothermal amplification
  • real time pcr
  • small molecule
  • high glucose
  • diabetic rats
  • circulating tumor cells