miR-193: A new weapon against cancer.
Monireh KhordadmehrRoya ShahbaziSanam SadreddiniBehzad BaradaranPublished in: Journal of cellular physiology (2019)
microRNAs (miRNAs) are known as a large group of short noncoding RNAs, which structurally consist of 19-22 nucleotides in length and functionally act as one of the main regulators of gene expression in important biological and physiological contexts like cell growth, apoptosis, proliferation, differentiation, movement (cell motility), and angiogenesis as well as disease formation and progression importantly in cancer cell invasion, migration, and metastasis. Among these notable tiny molecules, many studies recently presented the important role of the miR-193 family comprising miR-193a-3p, miR-193a-5p, miR-193b-3p, and miR-193b-5p in health and disease biological processes by interaction with special targeting and signaling, which mainly contribute as a tumor suppressor. Therefore, in the present paper, we review the functional role of this miRNA family in both health and disease conditions focusing on various tumor developments, diagnoses, prognoses, and treatment.
Keyphrases
- gene expression
- healthcare
- cell proliferation
- long non coding rna
- papillary thyroid
- public health
- mental health
- oxidative stress
- squamous cell
- dna methylation
- endothelial cells
- transcription factor
- escherichia coli
- single cell
- risk assessment
- staphylococcus aureus
- young adults
- cystic fibrosis
- cancer therapy
- social media
- biofilm formation
- wound healing
- pi k akt
- smoking cessation