Patients with HIV-associated cancers have evidence of increased T cell dysfunction and exhaustion prior to cancer diagnosis.
Omkar ChaudharyDiane TrottaKaicheng WangXun WangXiuping ChuChip BradleyJason OkuliczRyan C MavesKarl KronmannChristina M SchofieldJason M BlaylockYanhong DengKurt A SchalperSusan M KaechBrian AganAnuradha GanesanBrinda EmuPublished in: Journal for immunotherapy of cancer (2022)
, that is elevated 12 months before cancer diagnosis, suggesting that peripheral T cell alterations may serve as a biomarker of increased cancer risk among PLWH.