Pathological Tau transmission initiated by binding lymphocyte-activation gene 3.

Chan ChenRamhari KumbharHu WangXiuli YangKundlik GadhaveCyrus RastegarYasuyoshi KimuraAdam BehenskySruthi KatakamDeok JeongLiang WangAnthony WangRong ChenShu ZhangLingtao JinCreg J WorkmanDario A A VignaliOlga PletinkovaDavid W NauenPhilip C WongJuan C TroncosoMingyao YingValina L DawsonTed M DawsonXiaobo Mao

Published in: bioRxiv : the preprint server for biology (2023)

Lag3 is a neuronal receptor specific for Tau PFF, and is required for uptake, propagation and transmission of Tau pathology.

Keyphrases

cerebrospinal fluid
genome wide
gene expression
transcription factor
brain injury
subarachnoid hemorrhage
blood brain barrier