Genomic analysis of CTX-M-115 and OXA-23/-72 co-producing Acinetobacter baumannii, and their potential to spread resistance genes by natural transformation.
Jean-Baptiste VuillemenotMaxime BourRacha BeyrouthyRichard BonnetMaria-Halima LaaberkiXavier CharpentierRaymond RuimyPatrick PlésiatAnais PotronPublished in: The Journal of antimicrobial chemotherapy (2022)
This work highlights the propensity of CC78 isolates to collect multiple antibiotic resistance genes, to rearrange and to pass them to other A. baumannii strains via natural transformation. This process, along with mobile genetic elements, likely contributes to the considerable genomic plasticity of clinical strains, and to the diversity of molecular mechanisms sustaining their multidrug resistance.
Keyphrases
- acinetobacter baumannii
- antibiotic resistance genes
- multidrug resistant
- drug resistant
- pseudomonas aeruginosa
- escherichia coli
- wastewater treatment
- genome wide
- microbial community
- klebsiella pneumoniae
- copy number
- anaerobic digestion
- cystic fibrosis
- genetic diversity
- human health
- transcription factor
- genome wide analysis