Genome-wide association study identifies multiple risk loci for renal cell carcinoma.
Ghislaine SceloMark P PurdueKevin M BrownMattias JohanssonZhaoming WangJeanette E Eckel-PassowYuanqing YeJonathan N HofmannJiyeon ChoiMatthieu FollValerie GaborieauMitchell J MachielaLeandro M ColliPeng LiJoshua N SampsonBehnoush Abedi-ArdekaniCeline BesseHelene BlancheAnne BolandLaurie BurdetteAmelie ChabrierGeoffroy DurandFlorence Le Calvez-KelmEgor ProkhortchoukNivonirina RobinotKonstantin G SkryabinMagdalena B WozniakMeredith YeagerGordana Basta-JovanovicZoran DzamicLenka ForetovaIvana HolcatovaVladimir JanoutDana MatesAnush MukeriyaStefan RascuDavid ZaridzeVladimir BenckoCezary CybulskiEleonora FabianovaViorel JingaJolanta LissowskaJan LubinskiMarie NavratilovaPeter RudnaiNeonila Szeszenia-DabrowskaSimone BenhamouGeraldine Cancel-TassinOlivier CussenotLaura BagliettoHeiner BoeingKay-Tee KhawElisabete WeiderpassBorje LjungbergRaviprakash T SitaramFiona BruinsmaSusan J JordanGianluca SeveriIngrid WinshipKristian HveemLars J VattenTony FletcherKvetoslava KoppovaSusanna C LarssonAlicja WolkRosamonde E BanksPeter J SelbyDouglas F EastonPaul David Peter PharoahGabriella AndreottiLaura E Beane FreemanStella KoutrosDemetrius AlbanesSatu MännistöStephanie WeinsteinPeter E ClarkTodd L EdwardsLoren LipworthSusan M GapsturVictoria L StevensHallie CarolMatthew L FreedmanMark M PomerantzEunyoung ChoPeter KraftMark A PrestonKathryn M WilsonJ Michael GazianoHoward D SessoAmanda BlackNeal D FreedmanWen-Yi HuangJohn G AnemaRichard J KahnoskiBrian R LaneSabrina L NoyesDavid PetilloBin Tean TehUlrike PetersEmily WhiteGarnet L AndersonLisa JohnsonJuhua LuoJulie BuringI-Min LeeWong-Ho ChowLee E MooreChristopher WoodTimothy EisenMarc HenrionJames LarkinPoulami BarmanBradley C LeibovichToni K ChoueiriG Mark LathropNathaniel RothmanJean-Francois DeleuzeJames D McKayAlexander S ParkerXifeng WuRichard S HoulstonPaul BrennanStephen J ChanockPublished in: Nature communications (2017)
Previous genome-wide association studies (GWAS) have identified six risk loci for renal cell carcinoma (RCC). We conducted a meta-analysis of two new scans of 5,198 cases and 7,331 controls together with four existing scans, totalling 10,784 cases and 20,406 controls of European ancestry. Twenty-four loci were tested in an additional 3,182 cases and 6,301 controls. We confirm the six known RCC risk loci and identify seven new loci at 1p32.3 (rs4381241, P=3.1 × 10-10), 3p22.1 (rs67311347, P=2.5 × 10-8), 3q26.2 (rs10936602, P=8.8 × 10-9), 8p21.3 (rs2241261, P=5.8 × 10-9), 10q24.33-q25.1 (rs11813268, P=3.9 × 10-8), 11q22.3 (rs74911261, P=2.1 × 10-10) and 14q24.2 (rs4903064, P=2.2 × 10-24). Expression quantitative trait analyses suggest plausible candidate genes at these regions that may contribute to RCC susceptibility.