An amino acid-based supramolecular nanozyme by coordination self-assembly for cascade catalysis and enhanced chemodynamic therapy towards biomedical applications.
Enhui SongYongxin LiLili ChenXiaopeng LanChangshun HouChunlei LiuChunzhao LiuPublished in: Nanoscale advances (2021)
The clinical translation of chemodynamic therapy has been highly obstructed by the insufficient intracellular H 2 O 2 level in diseased tissues. Herein, we developed a supramolecular nanozyme through a facile one-step cooperative coordination self-assembly of an amphipathic amino acid and glucose oxidase (GOx) in the presence of Fe 2+ . The results demonstrated that the supramolecular nanozyme possessed cascade enzymatic activity ( i.e. , GOx and peroxidase), which could amplify the killing efficacy of hydroxyl radicals (˙OH) via self-supplying H 2 O 2 , finally achieving synergistic starvation-chemodynamic cancer therapy in vitro . Additionally, this cascade nanozyme also exhibited highly effective antibacterial activity on Escherichia coli ( E. coli ) and Staphylococcus aureus ( S. aureus ) without the need for additional H 2 O 2 . This work provided a promising strategy for the design and development of nanozymes for future biomedical applications.
Keyphrases
- amino acid
- escherichia coli
- cancer therapy
- staphylococcus aureus
- hydrogen peroxide
- water soluble
- energy transfer
- gene expression
- biofilm formation
- stem cells
- current status
- visible light
- metabolic syndrome
- type diabetes
- mesenchymal stem cells
- adipose tissue
- nitric oxide
- blood pressure
- pseudomonas aeruginosa
- klebsiella pneumoniae
- metal organic framework
- silver nanoparticles
- replacement therapy
- smoking cessation
- weight loss