Norepinephrine stimulation downregulates the β2 -adrenergic receptor-nitric oxide pathway in human pulmonary artery endothelial cells.
Wande YuYue GuPeiP ChenJie LuoPengfei LiuYue-Lin ChaoShao-Liang ChenHang ZhangPublished in: Journal of cellular physiology (2018)
These data provide a novel mechanism for NE-decreased endothelium-derived NO and NE-induced HPAEC proliferation that leads to PH-LHD, suggesting a potential therapeutic target for PH-LHD.
Keyphrases
- endothelial cells
- pulmonary artery
- high glucose
- nitric oxide
- coronary artery
- pulmonary hypertension
- pulmonary arterial hypertension
- nitric oxide synthase
- vascular endothelial growth factor
- signaling pathway
- electronic health record
- diabetic rats
- big data
- induced pluripotent stem cells
- drug induced
- data analysis
- deep learning