The Role of Efflux Pumps transporter in Multi-drug Resistant Tuberculosis: Mycobacterial memberane protein(MmpL5).
Parissa FarniaSaeid BesharatiPoopak FarinaSaman AyoubiMajid MarjaniJalaledin GhanaviPayam TabarsiAli Akbar VelayatiPublished in: International journal of mycobacteriology (2024)
Significant genetic mutation like insertion, deletion, and substitution within transmembrane transport protein MmpL5 (Rv0676) can change the functional balance of Eps and cause a reduction in drug susceptibility. This is the first report documenting a unique amino acid mutation (insertion and deletion ≥4-94) in Rv0676 among drug-resistant MTB. We suggest the changes in Mmpl5 (Rv0676) might occurred due to in-vivo sub-therapeutic drug stress within the host cell. Changes in MmpL5 are stable and detected through subsequent culture-positive specimens.
Keyphrases
- drug resistant
- mycobacterium tuberculosis
- amino acid
- multidrug resistant
- acinetobacter baumannii
- pulmonary tuberculosis
- protein protein
- genome wide
- cell therapy
- gene expression
- small molecule
- drug induced
- dna methylation
- human immunodeficiency virus
- hepatitis c virus
- mesenchymal stem cells
- bone marrow
- antiretroviral therapy