The Mitochondrial mitoNEET Ligand NL-1 Is Protective in a Murine Model of Transient Cerebral Ischemic Stroke.
Pushkar SaralkarAlexander MdzinarishviliTasneem A ArsiwalaYoon-Kwang LeePatrick G SullivanMark V PintiJohn M HollanderEric E KelleyXuefang RenHeng HuJames SimpkinsCandice BrownLori E HazlehurstJason D HuberWerner J GeldenhuysPublished in: Pharmaceutical research (2021)
As support of our hypothesis, as expected, NL-1 failed to reduce stroke infarct in a permanent photothrombotic occlusion model of stroke. This report demonstrates the potential therapeutic benefits of using mitoNEET ligands like NL-1 as novel mitoceuticals for treating reperfusion-injury with cerebral stroke.