Cardiac sympathetic neuronal damage precedes myocardial fibrosis in patients with Anderson-Fabry disease.

Massimo ImbriacoTeresa PellegrinoValentina PiscopoMario PetrettaAndrea PonsiglioneCarmela NappiMarta PugliaSerena Dell'AversanaEleonora RiccioLetizia SpinelliAntonio PisaniAlberto Cuocolo

Published in: European journal of nuclear medicine and molecular imaging (2017)

Sympathetic neuronal damage is frequent in AFD patients, and it may precede myocardial damage, such as fibrosis. Thus, 123I-MIBG imaging can be considered a challenging technique for early detection of cardiac involvement in AFD.

Keyphrases

left ventricular
oxidative stress
end stage renal disease
newly diagnosed
ejection fraction
chronic kidney disease
hypertrophic cardiomyopathy
prognostic factors
cerebral ischemia
patient reported outcomes
brain injury
blood brain barrier