Different responses of the blockade of the P2Y1 receptor with BPTU in human and porcine intestinal tissues and in cell cultures.

Sara TraserraClaudia BarberJane MaclnnesLucia ReleaLewis C MacPhersonMargaret R CunninghamPatri VergaraAnna AccarinoCharles KennedyMarcel Jiménez

Published in: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society (2021)

BPTU blocks purinergic responses elicited via P2Y1 receptors in cell cultures and in pig gastrointestinal tissue. However, the concentrations needed are higher in pig tissue compared to cell cultures and BPTU was ineffective in human colonic tissue.

Keyphrases

single cell
endothelial cells
cell therapy
gene expression
stem cells
induced pluripotent stem cells