MiR-146a reduces fibrosis after glaucoma filtration surgery in rats.
Ruiqi HanHuimin ZhongYang ZhangHuan YuYumeng ZhangShouyue HuangZijian YangYisheng ZhongPublished in: Journal of translational medicine (2024)
MiR-146a effectively reduced TGF-β1-induced fibrosis in rat Tenon's capsule fibroblasts in vitro and in vivo, potentially through the NF-KB-SMAD4 signaling pathway. MiR-146a shows promise as a novel therapeutic target for preventing fibrosis and improving the success rate of GFS.
Keyphrases
- cell proliferation
- long non coding rna
- signaling pathway
- long noncoding rna
- pi k akt
- transforming growth factor
- epithelial mesenchymal transition
- minimally invasive
- lps induced
- coronary artery bypass
- liver fibrosis
- high glucose
- machine learning
- diabetic rats
- big data
- immune response
- coronary artery disease
- inflammatory response
- surgical site infection
- deep learning
- toll like receptor