Physical activity, black carbon exposure, and DNA methylation in the FOXP3 promoter.
Stephanie Lovinsky-DesirKyung Hwa JungJacqueline R JezioroDavid Z TorroneMariangels de Planell-SaguerBeizhan YanFrederica P PereraAndrew G RundleMatthew S PerzanowskiSteven N ChillrudRachel L MillerPublished in: Clinical epigenetics (2017)
Physical activity in urban children appeared associated with lower FOXP3 promoter methylation, a possible indicator of greater Treg function, under conditions of high BC exposure. Reduced FOXP3 promoter methylation was associated with higher lung function. These findings suggest that physical activity may induce immunologic benefits, particularly for urban children with greater risk of impaired lung function due to exposure to higher air pollution. FOXP3 promoter buccal cell methylation may function as a useful biomarker of that benefit.
Keyphrases
- dna methylation
- lung function
- physical activity
- air pollution
- regulatory t cells
- genome wide
- cystic fibrosis
- chronic obstructive pulmonary disease
- gene expression
- particulate matter
- body mass index
- young adults
- dendritic cells
- copy number
- single cell
- transcription factor
- immune response
- cell therapy
- bone marrow
- stem cells