The therapeutic effects of blocking IGF-R1 on mice model of skin cancer.

Published in: The Journal of dermatological treatment (2020)

Blocking IGF-R1 has therapeutic effects against experimental skin cancer induced in mice. In addition, blocking IGF = R1 attenuated skin cancer-induced activation of tumor invasion markers.Key pointsIGF-1/IGF-R1is highly expressed in different cancers as skin cancer.Blocking IGF-R1 production ameliorated skin cancer.Blocking IGF-R1 attenuated skin cancer-induced activation of tumor invasion markers.

Keyphrases

skin cancer
pi k akt
binding protein
high glucose
growth hormone
diabetic rats
drug induced
endothelial cells
cell migration
signaling pathway
metabolic syndrome
young adults
insulin resistance