Optimal response to dimethyl fumarate is mediated by a reduction of Th1-like Th17 cells after 3 months of treatment.

María José MansillaJuan Navarro-BarriusoSilvia Presas-RodríguezAina Teniente-SerraBibiana Quirant-SanchezCristina Ramo-TelloEva María Martínez-Cáceres

Published in: CNS neuroscience & therapeutics (2019)

The optimal response to DMF is mediated by a shift to antiinflammatory and immunoregulatory profile, which puts forward Th1-like Th17 lymphocytes as a potential early biomarker of treatment response.

Keyphrases

induced apoptosis
cell cycle arrest
oxidative stress