PAF signaling plays a role in obesity-induced adipose tissue remodeling.

Kátia A CostaDébora R LacerdaAna Letícia Malheiros SilveiraLaís B MartinsMarina Chaves de OliveiraBarbara M RezendeZélia Menezes-GarciaFernanda L B MüggeAristóbolo M SilvaMauro M TeixeiraChristine RouaultVanessa PinhoGeneviève MarcelinKarine Clement Adaliene Versiani Matos Ferreira

Published in: International journal of obesity (2005) (2021)

Therefore, decreased PAFR signaling may favor an AT accumulation in humans and animal models. Importantly, PAFR signaling, mainly in non-hematopoietic cells, especially in adipocytes, appears to play a significant role in regulating diet-induced AT expansion.

Keyphrases

adipose tissue
insulin resistance
induced apoptosis
metabolic syndrome
type diabetes
weight loss
high fat diet induced
oxidative stress
physical activity
body mass index
cell cycle arrest
signaling pathway
endoplasmic reticulum stress
pi k akt