Synthesis of remote fluoroalkenyl ketones by photo-induced ring-opening addition of cyclic alkoxy radicals to fluorinated alkenes.

Fluoroalkenyl moieties are often used as carbonyl mimics in medicine preparation, and thus the development of facile routes for the synthesis of such compounds is of great importance. In this work, we report a photocatalytic ring-opening addition of cyclic alcohols to α-(trifluoromethyl)styrenes, which underwent a proton-coupled electron transfer and β-scission process, delivering a great variety of remote gem -difluoroalkenyl ketone derivatives. This methodology can also be applied in the reaction of gem -difluorostyrenes and 1,1,2-trifluorostyrenes to access monofluoro- and 1,2-difluoroalkenyl ketones.