Photonic Quasi-Crystal Fiber-Based Plasmonic Biosensor: a Platform for Detection of Coronavirus.

Since the coronavirus pandemic began, research groups worldwide developed diagnostic tests. One of the promising platforms for testing is an optical and plasmonic biosensor. Localized surface plasmon resonances owing to their highly concentrated field intensity provide highly sensitive devices. A beneficial approach to excite localized surface plasmon modes for field-based applications is using photonic crystal fibers while photonic quasi-crystals demonstrate a higher order of symmetry, the more isotropic Brillouin zone, and the easier achievement of photonic bandgap as compared with conventional photonic crystals. In this work, by exploiting a photonic quasi-crystal fiber, we are designing a surface plasmon resonance biosensor for the on-chip and real-time detection of coronaviruses. In our miniaturized design, a thin gold layer is employed on the outer layer of an air hole of a photonic quasi-crystal fiber with a 12-fold symmetry where the leakage of the fiber core mode can excite the surface plasmon resonance mode on the gold. According to three-dimensional finite-difference time-domain simulations, the proposed biosensor shows the sensitivity of 1172 nm/RIU in the detection of coronaviruses within the saliva. Moreover, the smallest detection limit obtained in the simulation is about 12 nm. These promising results altogether indicate that this reconfigurable and lab-on-a-chip platform can potentially be used in the detection of all kinds of coronaviruses.