Podoplanin (PDPN) affects the invasiveness of thyroid carcinoma cells by inducing ezrin, radixin and moesin (E/R/M) phosphorylation in association with matrix metalloproteinases.

Justyna SikorskaDamian GawełHanna DomekMagdalena RudzińskaBarbara Czarnocka

Published in: BMC cancer (2019)

Altogether, our data suggest that PDPN may play an important role in the control of invasion and migration of papillary thyroid carcinoma cells in association with the E/R/M, MMPs and MAPK kinases.

Keyphrases

papillary thyroid
lymph node metastasis
signaling pathway
oxidative stress
electronic health record
big data
protein kinase
deep learning
artificial intelligence