Pd(II)-Catalyzed enantioselective C-H olefination toward the synthesis of P -stereogenic phosphinamides.

P -Stereogenic phosphorus compounds are important structural elements in chiral ligands or organocatalysts. Herein, we report a Pd(II)-catalyzed enantioselective C-H olefination toward the synthesis of P -stereogenic phosphinamides using cheap commercially available L- p Glu-OH as a chiral ligand. A broad range of P -stereogenic phosphinamides were gained in good yields with high enantioselectivities (33 examples, up to 77% yield, 99% ee) via desymmetrization and kinetic resolution.