Stereotactic Radiosurgery for Women Older than 65 with Breast Cancer Brain Metastases.
Rituraj UpadhyayBrett G KlamerHaley K PerlowJulia R WhiteJose G BazanSachin M JhawarDukagjin M BlakajJohn C GreculaAndrea ArnettMariella A Mestres-VillanuevaErin H HealyEvan M ThomasArnab ChakravartiRaju R RavalMaryam LustbergNicole O WilliamsJoshua David PalmerSasha J BeyerPublished in: Cancers (2023)
Although older women had poorer OS than younger women, OS was similar after adjusting for KPS, extracranial progression, and systemic therapy; and there was no difference in rates of intracranial PFS, neurological deaths, and LMD in the different age groups. This study suggests that age alone may not play an independent role in treatment-selection and that outcomes for breast cancer patients with BMs and personalized decision-making including other clinical factors should be considered. Future studies are warranted to assess neurocognitive outcomes and other radiation treatment toxicities in older patients.
Keyphrases
- brain metastases
- polycystic ovary syndrome
- small cell lung cancer
- decision making
- physical activity
- breast cancer risk
- stem cells
- type diabetes
- current status
- metabolic syndrome
- radiation therapy
- young adults
- skeletal muscle
- pregnant women
- subarachnoid hemorrhage
- radiation induced
- glycemic control
- optical coherence tomography
- weight loss
- blood brain barrier
- cell therapy
- drug induced
- community dwelling