Integrating circulating T follicular memory cells and autoantibody repertoires for characterization of autoimmune disorders.
Emily M HarrisSarah ChamseddineAnne ChuLeetah SenkpeilMatthew NikiciukAmer Al-MusaBrian WoodsElif OzdoganSarife SakerDavid P Hoytema van KonijnenburgChristina S K YeeRyan NelsonPui Y LeeOlha HalyabarRebecca C HaleMegan Day-LewisLauren A HendersonAlan A NguyenMegan ElkinsToshiro K OhsumiMaria Gutierrez-ArcelusJanique M PeyperCraig D PlattRachael F GraceBrenna LaBereJanet ChouPublished in: medRxiv : the preprint server for health sciences (2024)
This study highlights two new approaches for assessing autoimmunity: measuring CD4+CXCR5+ cTfm subsets as well as total burden of autoantibodies. Our findings suggest that these approaches are particularly relevant to patients with rare autoimmune disorders for whom target antigens and prognosis are often unknown.