Nanophthalmos is a developmental ocular malformation that has been associated with high risks of uveal effusion syndrome and exudative retinal detachment (ERD). A variety of surgical procedures and systemic/topical steroids have been described as effective for treatment of ERD. However, the possibility of side effects should be considered. Here, we describe a patient with nanophthalmos who was treated for recurrent ERD during long-term follow-up, and we discuss non-surgical treatment options that are available in such cases. A 43-year-old woman with bilateral nanophthalmos exhibited ERD in her right eye for one month. After partial thickness sclerectomy with central sclerostomy, the retina was completely reattached. However, ERD recurred 3 years later. The patient refused surgery; therefore, we employed conservative treatment of topical nonsteroidal anti-inflammatory drugs (NSAIDs) and observation. One month later, the retina was completely reattached. To the best of our knowledge, no previous report has described resolution of recurrent ERD in a patient with nanophthalmos using NSAIDs during long-term follow-up after successful surgical treatment. Our success using this approach suggests that it could be used as alternative treatment for ERD in patients with nanophthalmos before application of further treatments.
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