Interleukin-5 drives glycolysis and reactive oxygen species-dependent citric acid cycling by eosinophils.
Nicholas JonesEmma E VincentLindsey C FelixJames G CroninLouis M ScottPaul S HolePaige LacyCatherine A ThorntonPublished in: Allergy (2020)
We demonstrate for the first time that eosinophils are capable of metabolic plasticity, evidenced by increased glucose-derived lactate production upon ROS inhibition. Collectively, this study reveals a role for both glycolysis and mitochondrial metabolism in cytokine-stimulated eosinophils. Selective targeting of eosinophil metabolism may be of therapeutic benefit in eosinophil-mediated diseases and regulation of tissue homeostasis.