Metastatic tumor antigen 1 contributes to hepatocarcinogenesis posttranscriptionally through RNA-binding function.

Yung-Tsung LiChun-Jen LiuJia-Horng KaoLi-Feng LinHui-Chu TuChih-Chiang WangPo-Hsi HuangHuei-Ru ChengPei-Jer ChenDing-Shinn ChenHui-Lin Wu

Published in: Hepatology (Baltimore, Md.) (2022)

MTA1 is a generic RNA-binding protein. Cytoplasmic MTA1 and its binding to MYC is associated with early recurrence in patients with HBV-HCC. This function enables it to regulate gene expression posttranscriptionally and contributes to hepatocarcinogenesis.

Keyphrases

binding protein
gene expression
hepatitis b virus
squamous cell carcinoma
small cell lung cancer
dna methylation
transcription factor
nucleic acid
free survival