Effect of Aspirin on All-Cause Mortality in the Healthy Elderly.
John J McNeillMark R NelsonRobyn L WoodsJessica E LockeryRory WolfeChristopher M ReidBrenda KirpachRaj C ShahDiane G IvesElsdon StoreyJoanne RyanAndrew M TonkinAnne B NewmanJeff D WilliamsonKaren L MargolisMichael E ErnstWalter P AbhayaratnaNigel StocksSharyn M FitzgeraldSuzanne G OrchardRuth E TrevaksLawrence J BeilinGeoffrey A DonnanPeter GibbsColin I JohnstonBarbara RadziszewskaRichard GrimmAnne M Murraynull nullPublished in: The New England journal of medicine (2018)
Higher all-cause mortality was observed among apparently healthy older adults who received daily aspirin than among those who received placebo and was attributed primarily to cancer-related death. In the context of previous studies, this result was unexpected and should be interpreted with caution. (Funded by the National Institute on Aging and others; ASPREE ClinicalTrials.gov number, NCT01038583 .).