Protocadherin 20 maintains intestinal barrier function to protect against Crohn's disease by targeting ATF6.

Shanshan HuangZhuo XieJing HanHuiling WangGuang YangManying LiGaoshi ZhouYing WangLixuan LiLi LiZhirong ZengJun YuMinhu ChenShenghong Zhang

Published in: Genome biology (2023)

PCDH20 is an essential factor in maintaining intestinal epithelial homeostasis and barrier integrity. Specifically, PCDH20 helps to protect against colitis by tightening adherens junctions through the ATF6/CHOP/β-catenin/p-p120-catenin axis.

Keyphrases

epithelial mesenchymal transition
transcription factor
cell proliferation
endoplasmic reticulum stress
diffuse large b cell lymphoma
single molecule
signaling pathway