Estrogen receptor-α signaling in tanycytes lies at the crossroads of fertility and metabolism.
Daniela FernandoisMariam RusidzéHelge Mueller-FielitzFlorent SauveEleonora DeligiaMauro S B SilvaFlorence EvrardAurelio Franco-GarcíaDaniele MazurInes Martinez-CorralNathalie JouyS RasikaClaude-Alain MauragePaolo GiacobiniRuben NogueirasBenedicte DehouckMarkus SchwaningerFrancoise LenfantVincent PrevotPublished in: Metabolism: clinical and experimental (2024)
Our investigation reveals that tanycytes, specialized glial cells in the brain, are key interpreters of estrogen signals for orexigenic NPY neurons in the hypothalamus. Disrupting tanycytic estrogen receptors not only alters fertility in female mice but also impairs the ability of estrogens to suppress appetite. This work thus sheds light on the critical role played by tanycytes in bridging the hormonal regulation of cyclic reproductive function and appetite/feeding behavior. This understanding may have potential implications for age-related metabolic deregulation after menopause.
Keyphrases
- estrogen receptor
- induced apoptosis
- weight loss
- body weight
- cell cycle arrest
- childhood cancer
- white matter
- palliative care
- spinal cord
- high fat diet induced
- endoplasmic reticulum stress
- resting state
- cell death
- spinal cord injury
- oxidative stress
- signaling pathway
- insulin resistance
- metabolic syndrome
- young adults
- multiple sclerosis
- brain injury