Does the intensity of dissociation predict antidepressant effects 24 hours after infusion of racemic ketamine and esketamine in treatment-resistant depression? A secondary analysis from a randomized controlled trial.

Mariana V F EchegarayRodrigo P MelloGuilherme M MagnavitaGustavo C LealFernanda S Correia-MeloAna Paula Jesus-NunesFlávia VieiraIgor D BandeiraAna Teresa Caliman-FontesManuela TellesLívia N F Guerreiro-CostaRoberta Ferrari MarbackBreno Souza-MarquesDaniel H Lins-SilvaCassio Santos-LimaTaiane de Azevedo CardosoFlávio KapczinskiAcioly L T LacerdaLucas C Quarantini

Published in: Trends in psychiatry and psychotherapy (2023)

We suggest a positive relationship between dissociation intensity, measured by CADSS, and antidepressant effect 24 hours after ketamine and esketamine infusion for a CADSS score of up to 15 points.

Keyphrases

major depressive disorder
high intensity
low dose
pain management
electron transfer
depressive symptoms
bipolar disorder
chronic pain
physical activity