SCUBE3 downregulation modulates hepatocellular carcinoma by inhibiting CCNE1 via TGFβ/PI3K/AKT/GSK3β pathway.

Pan XuAoran LuoChuan XiongHong RenLiang YanQiang Luo

Published in: Cancer cell international (2022)

SCUBE3 promotes HCC development by regulating CCNE1 via TGFβ/PI3K/AKT/GSK3β pathway. In addition, SCUBE3 may be a new molecular target for the clinical diagnosis and treatment of HCC.

Keyphrases

pi k akt
signaling pathway
cell proliferation
transforming growth factor
cell cycle arrest
epithelial mesenchymal transition
cell death