Evaluation of a Genetic Risk Score for Diagnosis of Psoriatic Arthritis.

Mary Patricia SmithKaren LyQuinn ThibodeauxKristen BeckEric YangIsabelle SanchezJoanne NitithamTina BhutaniWilson Liao

Published in: Journal of psoriasis and psoriatic arthritis (2020)

The AUROC of 56.9% for HLA-only wGRS indicates that this approach has the greatest power in discriminating PsA from PsO among these models. Given that an AUROC of 56.9% is quite modest, this study suggests that using a small number of well-validated genetic loci provides limited predictive power for PsA, and that future approaches may benefit from using a larger number of genetic loci.

Keyphrases

genome wide
prostate cancer
dna methylation
copy number
radical prostatectomy
gene expression