Deleterious alterations in homologous recombination repair genes and efficacy of platinum-based chemotherapy in biliary tract cancers.

Carmen BelliLuca Boscolo BieloMatteo RepettoEdoardo CriminiRaimondo ScaliaAnna DianaJessica OreficeLiliana AscioneGloria PellizzariNicola FuscoMassimo BarberisBruno DanieleElena Guerini-RoccoCurigliano Giuseppe

Published in: The oncologist (2024)

HR-/DDR-genes, when assessed with regular tumor-only NGS panels, provide limited clinical validity to identify patients with BTC more likely to benefit from platinum-based chemotherapy.

Keyphrases

genome wide
dna repair
dna damage
locally advanced
genome wide identification
bioinformatics analysis
genome wide analysis
dna methylation
squamous cell carcinoma
oxidative stress
transcription factor