Activating transcription factor 3 inhibits NF‑κB p65 signaling pathway and mediates apoptosis and cell cycle arrest in cervical cancer cells.

Amirhossein Akbarpour ArsanjaniHaniyeh AbueiAbbas Behzad-BehbahaniZahra BagheriRita ArabsolgharAli Farhadi

Published in: Infectious agents and cancer (2022)

ATF3 acts as a tumor suppressor factor in HPV16-infected Ca Ski cells and exerts anti-cancer effects on HPV16-related cervical cancer cells potentially by hindering cell growth and inducing cell cycle arrest through the down-regulation of NF-κB. Our results suggest that ATF3 induction or NF-κB suppression may be useful targets for HPV16-related cervical cancer prevention and treatment.

Keyphrases

cell cycle arrest
pi k akt
signaling pathway
transcription factor
induced apoptosis
cell death
cell proliferation
high grade
epithelial mesenchymal transition
endoplasmic reticulum stress
oxidative stress
lps induced
immune response
protein kinase
smoking cessation