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Oocyte-specific deletion of eukaryotic translation initiation factor 5 causes apoptosis of mouse oocytes within the early-growing follicles by mitochondrial fission defect-reactive oxygen species-DNA damage.

Weiyong WangHuiyu LiuShuang LiuTiantian HaoYing WeiHongwei WeiWenjun ZhouXiaodan ZhangXiaoqiong HaoMeijia Zhang
Published in: Clinical and translational medicine (2024)
Eif5 deletion in oocytes leads to arrest in oocyte growth and follicle development. Eif5 deletion in oocytes impairs the translation of mitochondrial fission-related proteins, followed by mitochondrial dysfunction. Depletion of Eif5 causes oocyte apoptosis via ROS accumulation and DNA damage response pathway.
Keyphrases
  • oxidative stress
  • dna damage
  • dna damage response
  • reactive oxygen species
  • dna repair
  • cell death
  • cell cycle arrest
  • endoplasmic reticulum stress
  • cell proliferation
  • drug induced