Comparative Safety and Efficacy of Low/Moderate-Intensity Statin plus Ezetimibe Combination Therapy vs. High-Intensity Statin Monotherapy in Patients with Atherosclerotic Cardiovascular Disease: An Updated Meta-Analysis.

Ishaque HameedSyeda Ayesha ShahAshnah AijazHasan MushahidSyed Husain FarhanMuhammad DadaAdam Bilal KhanReeha AmjadFawad AlviMustafa MurtazaZaid ZuberiMohammad Hamza

Published in: American journal of cardiovascular drugs : drugs, devices, and other interventions (2024)

This meta-analysis demonstrated that the use of low/moderate-intensity statin combination therapy significantly reduced LDL-C levels compared with high-intensity statin monotherapy, making it preferable for patients with related risks. However, further trials are encouraged to evaluate potential adverse effects associated with combined therapy.

Keyphrases

high intensity
combination therapy
cardiovascular disease
systematic review
low density lipoprotein
resistance training
coronary artery disease
meta analyses
cardiovascular events
type diabetes
cardiovascular risk factors
human health
stem cells
risk assessment
climate change