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Primary EWS/PNET of the lung with TP53 germline and SKT11 somatic mutation: A case report and review of the literature.

Shuangping ZhangYun ChenShiping GuoKe-Neng Chen
Published in: Thoracic cancer (2021)
Primary pulmonary EWS/PNET is extremely rare. This report describes a 20 year-old man with primary pulmonary EWS/PNET with TP53 germline and SKT11 somatic mutation. After four neoadjuvant chemotherapy cycles (VAC with alternating IE) combined with anlotinib, a left pneumonectomy was performed. Maintenance anlotinib monotherapy was then continued with no sign of recurrence to date. It is suggested that before the treatment and prognosis of children or young adults with primary EWS/PNET of the lung that consideration should be given to genetic testing.
Keyphrases
  • neoadjuvant chemotherapy
  • pulmonary hypertension
  • dna repair
  • young adults
  • lymph node
  • squamous cell carcinoma
  • locally advanced
  • gene expression
  • combination therapy
  • radiation therapy
  • early stage
  • smoking cessation