Autopsy and Imaging Studies of Mucus in Asthma. Lessons Learned about Disease Mechanisms and the Role of Mucus in Airflow Obstruction.
Eleanor M DunicanDavid C WatchornJohn V FahyPublished in: Annals of the American Thoracic Society (2019)
Autopsy studies in fatal asthma have clearly documented the central role of airway plugging with pathologic mucus in the pathophysiology of death from asthma, but the role of mucus plugs in chronic severe asthma has been less well understood. Recently, multidetector computerized tomography imaging of the lungs has emerged as a valuable method to visualize mucus plugs in asthma. These multidetector computerized tomography data have revealed mucus plugs as a common occurrence in severe forms of asthma. In addition, an image-based mucus plug scoring system shows that mucus plugs are strongly associated with measures of airflow obstruction and with biomarkers of type 2 cytokine and eosinophilic inflammation. These data provide a rationale for treating airflow obstruction in severe asthma with mucolytics, and they also raise the possibility that treatments that target type 2 inflammation may decrease mucus plugs in asthma.
Keyphrases
- chronic obstructive pulmonary disease
- lung function
- allergic rhinitis
- computed tomography
- high resolution
- oxidative stress
- electronic health record
- clinical trial
- cystic fibrosis
- big data
- squamous cell carcinoma
- radiation therapy
- machine learning
- risk assessment
- clinical decision support
- lymph node
- single cell
- data analysis
- locally advanced