Dalteparin as a Novel Therapeutic Agent to Prevent Diabetic Encephalopathy by Targeting Oxidative Stress and Inflammation.
Motahareh ZeinivandArezo NahavandiTourandokht Baluchnejad MojaradMehrdad RoghaniFereshteh GolabPublished in: Basic and clinical neuroscience (2020)
Treatment with dalteparin improved the cognitive dysfunctions and symptoms of Alzheimer disease in STZ-induced diabetic rats by appropriately modulating and reducing oxidative stress and neuroinflammation. This may enhance the existing knowledge of therapeutics to reduce cognitive impairment in diabetes and is suggested to be a potential therapeutic agent in diabetes.
Keyphrases
- diabetic rats
- oxidative stress
- cognitive impairment
- type diabetes
- cardiovascular disease
- glycemic control
- dna damage
- ischemia reperfusion injury
- induced apoptosis
- healthcare
- early onset
- lipopolysaccharide induced
- lps induced
- heat shock
- combination therapy
- wound healing
- physical activity
- brain injury
- weight loss
- drug induced
- stress induced