Restoration of primary cilia in obese adipose-derived mesenchymal stem cells by inhibiting Aurora A or extracellular signal-regulated kinase.
Andreas RitterNina-Naomi KreisSusanne RothAlexandra FriemelLukas JenneweinChristine EichbaumChristine SolbachFrank LouwenJuping YuanPublished in: Stem cell research & therapy (2019)
This work describes a novel phenomenon whereby the primary cilium of obese ASCs is rescuable by the low-dose inhibition of Aurora A or Erk1/2, restoring functional ASCs with increased stemness. These cells might be able to improve tissue homeostasis in obese patients and thereby ameliorate obesity-associated diseases. Additionally, these functionally restored obese ASCs could be useful for novel autologous mesenchymal stem cell-based therapies.
Keyphrases
- obese patients
- bariatric surgery
- weight loss
- gastric bypass
- roux en y gastric bypass
- low dose
- adipose tissue
- metabolic syndrome
- signaling pathway
- insulin resistance
- induced apoptosis
- type diabetes
- mesenchymal stem cells
- bone marrow
- stem cells
- epithelial mesenchymal transition
- cell therapy
- cell proliferation
- cancer stem cells