Protecting-group-free S-glycosylation towards thioglycosides and thioglycopeptides in water.

Gao-Lan ZhangMadhusudhan Reddy GadiXikai CuiDing LiuJiabin ZhangVarma SaikamChristopher GibbonsPeng G WangLei Li

Published in: Green chemistry : an international journal and green chemistry resource : GC (2021)

A facile and green S-glycosylation method has been developed featuring protecting-group-free and proceeding-in-water like enzymatic synthesis. Glycosylation of fluoride donors with thiol sugar acceptors using Ca(OH)2 as a promoter afforded various thioglycosides in good yields with exclusive stereoselectivity. This method also enabled the successful production of S-linked oligosaccharides and S-linked glycopeptides.

Keyphrases

dna methylation
hydrogen peroxide
drinking water
transcription factor
quantum dots
reduced graphene oxide
highly efficient
solar cells
metal organic framework